{
  "_id": "6a1f02eab401979e7341b41f",
  "Package": "CohortPlat",
  "Type": "Package",
  "Title": "Simulation of Cohort Platform Trials for Combination Treatments",
  "Version": "1.0.6",
  "Authors@R": "c(person(\"Elias Laurin\", \"Meyer\", email = \"elias.meyer@meduniwien.ac.at\", role = c(\"aut\",\"cre\")), \nperson(\"Peter\", \"Mesenbrink\", role = \"ctb\"),\nperson(\"Cornelia\", \"Dunger-Baldauf\", role = \"ctb\"),\nperson(\"Ekkehard\", \"Glimm\", role = \"ctb\"),\nperson(\"Franz\", \"Koenig\", role = \"ctb\"))",
  "Author": "Elias Laurin Meyer [aut, cre], Peter Mesenbrink [ctb], Cornelia\nDunger-Baldauf [ctb], Ekkehard Glimm [ctb], Franz Koenig [ctb]",
  "Maintainer": "Elias Laurin Meyer <elias.meyer@meduniwien.ac.at>",
  "Description": "A collection of functions dedicated to simulating\nstaggered entry platform trials whereby the treatment under\ninvestigation is a combination of two active compounds. In\norder to obtain approval for this combination therapy,\nsuperiority of the combination over the two active compounds\nand superiority of the two active compounds over placebo need\nto be demonstrated. A more detailed description of the design\ncan be found in Meyer et al. <DOI:10.1002/pst.2194> and a\nmanual in Meyer et al. <arXiv:2202.02182>.",
  "License": "GPL-3",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.1.2",
  "URL": "https://el-meyer.github.io/CohortPlat/,\nhttps://github.com/el-meyer/CohortPlat",
  "BugReports": "https://github.com/el-meyer/CohortPlat/issues",
  "VignetteBuilder": "knitr",
  "Config/pak/sysreqs": "cmake make libicu-dev libuv1-dev libssl-dev",
  "Repository": "https://el-meyer.r-universe.dev",
  "Date/Publication": "2025-05-22 12:59:55 UTC",
  "RemoteUrl": "https://github.com/el-meyer/cohortplat",
  "RemoteRef": "HEAD",
  "RemoteSha": "68fca7544370105747cd06f976cb38756e9090e5",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-18 08:15:56 UTC",
    "User": "root"
  },
  "MD5sum": "f2a03183e6d5be51bd822dc8f39d2515",
  "_user": "el-meyer",
  "_type": "src",
  "_file": "CohortPlat_1.0.6.tar.gz",
  "_fileid": "0976991609e5969e72cf25624640acd42baf2c6b2ac3624e1d81648520ccbed6",
  "_filesize": 215539,
  "_sha256": "0976991609e5969e72cf25624640acd42baf2c6b2ac3624e1d81648520ccbed6",
  "_created": "2026-05-18T08:15:56.000Z",
  "_published": "2026-06-02T16:20:58.321Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 79119005186,
      "time": 140,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7052728891"
    },
    {
      "job": 79119005151,
      "time": 139,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7052728124"
    },
    {
      "job": 79119005931,
      "time": 130,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7052719892"
    },
    {
      "job": 79119005206,
      "time": 124,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7052717323"
    },
    {
      "job": 79119004480,
      "time": 306,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7052684990"
    },
    {
      "job": 79119004157,
      "time": 124,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7363571081"
    },
    {
      "job": 79119005233,
      "time": 117,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7052721601"
    },
    {
      "job": 79119006148,
      "time": 96,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7052715966"
    },
    {
      "job": 79119005775,
      "time": 81,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7052710695"
    }
  ],
  "_buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/el-meyer/cohortplat",
  "_commit": {
    "id": "68fca7544370105747cd06f976cb38756e9090e5",
    "author": "Elias Laurin Meyer <73820185+el-meyer@users.noreply.github.com>",
    "committer": "GitHub <noreply@github.com>",
    "message": "Update README.md",
    "time": 1747918795
  },
  "_maintainer": {
    "name": "Elias Laurin Meyer",
    "email": "elias.meyer@meduniwien.ac.at",
    "login": "el-meyer",
    "description": "",
    "uuid": 73820185
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.5.0",
      "role": "Depends"
    },
    {
      "package": "dplyr",
      "role": "Imports"
    },
    {
      "package": "purrr",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "role": "Imports"
    },
    {
      "package": "plotly",
      "role": "Imports"
    },
    {
      "package": "tidyr",
      "role": "Imports"
    },
    {
      "package": "parallel",
      "role": "Imports"
    },
    {
      "package": "doParallel",
      "role": "Imports"
    },
    {
      "package": "foreach",
      "role": "Imports"
    },
    {
      "package": "openxlsx",
      "role": "Imports"
    },
    {
      "package": "forcats",
      "role": "Imports"
    },
    {
      "package": "epitools",
      "role": "Imports"
    },
    {
      "package": "zoo",
      "role": "Imports"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "DT",
      "role": "Suggests"
    },
    {
      "package": "gtools",
      "role": "Suggests"
    }
  ],
  "_owner": "el-meyer",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-21",
      "n": 3
    }
  ],
  "_tags": [
    {
      "name": "v1.0.7",
      "date": "2025-05-22"
    }
  ],
  "_topics": [
    "clinical-trials",
    "platform-trials",
    "simulations"
  ],
  "_stars": 0,
  "_contributors": [
    {
      "user": "el-meyer",
      "count": 24,
      "uuid": 73820185
    },
    {
      "user": "olivroy",
      "count": 1,
      "uuid": 52606734
    }
  ],
  "_userbio": {
    "uuid": 73820185,
    "type": "user",
    "name": "Elias Laurin Meyer"
  },
  "_downloads": {
    "count": 298,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/CohortPlat"
  },
  "_devurl": "https://github.com/el-meyer/cohortplat",
  "_pkgdown": "https://el-meyer.github.io/CohortPlat/",
  "_searchresults": 3,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/CohortPlat.html",
    "extra/contents.json",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/el-meyer/cohortplat",
  "_realowner": "el-meyer",
  "_cranurl": true,
  "_releases": [
    {
      "version": "1.0.0",
      "date": "2021-01-25"
    },
    {
      "version": "1.0.1",
      "date": "2021-05-10"
    },
    {
      "version": "1.0.3",
      "date": "2021-05-17"
    },
    {
      "version": "1.0.4",
      "date": "2022-02-09"
    },
    {
      "version": "1.0.5",
      "date": "2022-02-14"
    }
  ],
  "_exports": [
    "make_decision_trial",
    "plot_trial",
    "simulate_trial",
    "trial_ocs"
  ],
  "_help": [
    {
      "page": "make_decision_trial",
      "title": "Checks whether decision criteria are met and updates trial results accordingly.",
      "topics": [
        "make_decision_trial"
      ]
    },
    {
      "page": "plot_trial",
      "title": "Plots the cohort trial study overview given stage data.",
      "topics": [
        "plot_trial"
      ]
    },
    {
      "page": "simulate_trial",
      "title": "Simulates the cohort trial.",
      "topics": [
        "simulate_trial"
      ]
    },
    {
      "page": "trial_ocs",
      "title": "Calculates the operating characteristics of the cohort trial",
      "topics": [
        "trial_ocs"
      ]
    }
  ],
  "_readme": "https://github.com/el-meyer/cohortplat/raw/HEAD/README.md",
  "_rundeps": [
    "askpass",
    "base64enc",
    "bslib",
    "cachem",
    "cli",
    "codetools",
    "cpp11",
    "crosstalk",
    "curl",
    "data.table",
    "digest",
    "doParallel",
    "dplyr",
    "epitools",
    "evaluate",
    "farver",
    "fastmap",
    "fontawesome",
    "forcats",
    "foreach",
    "fs",
    "generics",
    "ggplot2",
    "glue",
    "gtable",
    "highr",
    "htmltools",
    "htmlwidgets",
    "httr",
    "isoband",
    "iterators",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "later",
    "lattice",
    "lazyeval",
    "lifecycle",
    "magrittr",
    "memoise",
    "mime",
    "openssl",
    "openxlsx",
    "otel",
    "pillar",
    "pkgconfig",
    "plotly",
    "promises",
    "purrr",
    "R6",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "rlang",
    "rmarkdown",
    "S7",
    "sass",
    "scales",
    "stringi",
    "stringr",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "tinytex",
    "utf8",
    "vctrs",
    "viridisLite",
    "withr",
    "xfun",
    "yaml",
    "zip",
    "zoo"
  ],
  "_vignettes": [
    {
      "source": "my-vignette.Rmd",
      "filename": "my-vignette.html",
      "title": "CohortPlat",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Simulation of cohort platform trials investigating combination treatments with a common backbone versus placebo",
        "Trial Design Overview",
        "Overview of all simulation parameters",
        "General simulation assumptions",
        "Cohort Structure",
        "Recruitment Speed",
        "Availability of Endpoints",
        "Design parameters and treatment efficacy assumptions",
        "Target Product Profile",
        "Cohort Allocation Ratios",
        "Sample Sizes",
        "Additional Cohort Parameters",
        "Safety Stopping",
        "Level of Data Sharing Across Cohorts",
        "Platform Stopping Rule",
        "Treatment efficacy assumptions",
        "Sensitivity and Specificity of Surrogate Interim Endpoint",
        "make_decision_trial()",
        "General",
        "Variables",
        "Examples",
        "Bayesian",
        "Frequentist",
        "simulate_trial()",
        "Example 1",
        "Example 2",
        "plot_trial()",
        "trial_ocs()",
        "Computed operating characteristics"
      ],
      "created": "2020-12-14 10:03:44",
      "modified": "2022-02-09 14:08:42",
      "commits": 4
    }
  ],
  "_score": 3.6989700043360187,
  "_indexed": true,
  "_nocasepkg": "cohortplat",
  "_universes": [
    "el-meyer"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.0.6",
      "date": "2026-05-18T08:18:13.000Z",
      "distro": "noble",
      "commit": "68fca7544370105747cd06f976cb38756e9090e5",
      "fileid": "4ada8c65a0022917472973a81e1dc53cb46ed776aedaa1e2b5dd794441902851",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.0.6",
      "date": "2026-05-18T08:18:11.000Z",
      "distro": "noble",
      "commit": "68fca7544370105747cd06f976cb38756e9090e5",
      "fileid": "8d6438c69b9dd1d77a61e87c6dab5b864a95d004be93526d3d55bce1d7cfefeb",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.0.6",
      "date": "2026-05-18T08:17:51.000Z",
      "commit": "68fca7544370105747cd06f976cb38756e9090e5",
      "fileid": "9aca65b9a3dbee4f4db663569e9808fef6896fd703a13a61e80c3bb61b4c2c3b",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.0.6",
      "date": "2026-05-18T08:17:32.000Z",
      "commit": "68fca7544370105747cd06f976cb38756e9090e5",
      "fileid": "71a792e7122218a20e77d371ed453936d612e70ff53aac2cd45cdfd3c8b67608",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.0.6",
      "date": "2026-05-18T08:17:41.000Z",
      "commit": "68fca7544370105747cd06f976cb38756e9090e5",
      "fileid": "5916c8230fc7d7fd9cbd92b8611ce4587a43d4650433e6ea51271174344e7785",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.0.6",
      "date": "2026-05-18T08:17:22.000Z",
      "commit": "68fca7544370105747cd06f976cb38756e9090e5",
      "fileid": "78d3977db03204baabd543afc33c4bdb73b4d0cc713ffeed0a7874f49e95bf8b",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.0.6",
      "date": "2026-05-18T08:17:09.000Z",
      "commit": "68fca7544370105747cd06f976cb38756e9090e5",
      "fileid": "2637020d43517ef75cb7d617c29a0c427a8697bd159099893f2ee835f42fc908",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.0.6",
      "date": "2026-06-02T16:20:34.000Z",
      "commit": "68fca7544370105747cd06f976cb38756e9090e5",
      "fileid": "123cd2458ce2f4c58daa7d16e867a609195bde77312f6de33f99e9422ac113ea",
      "status": "success",
      "buildurl": "https://github.com/r-universe/el-meyer/actions/runs/26021455930"
    }
  ]
}