airship - Visualization of Simulated Datasets with Multiple Simulation Input Dimensions
Plots simulation results of clinical trials. Its main feature is allowing users to simultaneously investigate the impact of several simulation input dimensions through dynamic filtering of the simulation results. A more detailed description of the app can be found in Meyer et al. <DOI:10.1016/j.softx.2023.101347> or the vignettes on 'GitHub'.
Last updated 2 months ago
clinical-trialsggplot2interactiveinteractive-visualizationssimulationvisualization
5.48 score 3 stars 2 scripts 296 downloadsCohortPlat - Simulation of Cohort Platform Trials for Combination Treatments
A collection of functions dedicated to simulating staggered entry platform trials whereby the treatment under investigation is a combination of two active compounds. In order to obtain approval for this combination therapy, superiority of the combination over the two active compounds and superiority of the two active compounds over placebo need to be demonstrated. A more detailed description of the design can be found in Meyer et al. <DOI:10.1002/pst.2194> and a manual in Meyer et al. <arXiv:2202.02182>.
Last updated 1 years ago
clinical-trialsplatform-trialssimulations
3.70 score 3 scripts 261 downloadscats - Cohort Platform Trial Simulation
Cohort plAtform Trial Simulation whereby every cohort consists of two arms, control and experimental treatment. Endpoints are co-primary binary endpoints and decisions are made using either Bayesian or frequentist decision rules. Realistic trial trajectories are simulated and the operating characteristics of the designs are calculated.
Last updated 1 years ago
clinical-trialsplatform-trialssimulations
2.85 score 14 scripts 256 downloadsearlygating - Properties of Bayesian Early Gating Designs
Computes the most important properties of four 'Bayesian' early gating designs (two single arm and two randomized controlled designs), such as minimum required number of successes in the experimental group to make a GO decision, operating characteristics and average operating characteristics with respect to the sample size. These might aid in deciding what design to use for the early phase trial.
Last updated 3 years ago
2.70 score 8 scripts 244 downloads